Based on Google Scholar as of July 28, 2020
Total citations: 26745, h-index: 63
Peer-Reviewed Publications:
122: Schmidlin CJ, Zeng T, Liu P, Wei Y, Dodson M, Chapman E, Zhang DD. Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX9. Toxicol Appl Pharmacol. 2020. PMID:32682831
121: Liu P, Dodson M, Dang D, Chapman E, Zhang DD. NRF2 negatively regulates primary ciliogenesis and hedgehog signalng. PLoS Biol. 2020. PMID:32053600
120: Rodrigues SD, Santos SS, Meireles T, Romero N, Glorieux G, Pecoits-Filho R, Zhang DD, Nakao LS. Uremic toxins promote accumulation of oxidized protein and increased sensitivity to hydrogen peroxide in endothelial cells by impairing the autophagic flux. Biochem Biophys Res Commun. 2019. PMID:31837804.
119: Liu P, Kerins MJ, Tian W, Neupana D, Zhang DD*, Ooi A*. Differential and overlapping targets of the transcriptional regulators NRF1, NRF2, and NRF3 in human cells. J Biol Chem. 2019. PMID:31628195.
118: Liu P, Tian W, Tao S, Tillotson J, Wijeratne EMK, Gunatilaka AAL, Zhang DD*, Chapman E*. Non-covalent NRF2 Activation Confers Greater Cellular Protection than Covalent Activation. Cell Chem Biol. 2019. PMID:31402317
117: Shi T, Wijeratne EMK, Solano C, Ambrose AJ, Ross AB, Norwood C, Orido CK, Grigoryan T, Tillotson J, Kang M, Luo G, Keegan BM, Hu W, Blagg BSJ, Zhang DD, Gunatilaka AAL, Chapman E. An Isoform-Selective PTP1B Inhibitor Derived from Nitrogen-Atom Augmentation of Radicicol. Biochemistry. 2019. PMID:31298844
116: Kerins MJ, Liu P, Tian W, Mannheim W, Zhang DD*, Ooi A*. Genome wide CRISPR screen reveals autophagy disruption as the convergence mechanism that regulates the NRF2 transcription factor. Mol Cell Biol. 2019. PMID: 31010806
115: Liu P, de la Vega MR, Dodson M, Yue F, Shi B, Fang D, Chapman E, Liu L, Zhang DD. Spermidine confers liver protection by enhancing NRF2 signaling through a MAP1S-mediated non-canonical mechanism. Hepatology. 2019. PMID:30873635
114: Shi T, Kaneko L, Sandino M, Busse R, Zhang M, Mason D, Machulis J, Ambrose AJ, Zhang DD, Chapman E. One-step synthesis of thieno[2,3-d]pyrimidin-4(3H)-ones via a catalytic four-component reaction of ketones, ethyl cyanoacetate, S8 and formamide. ACS Sustain Chem. Eng. 2019. 7, 1524-1528.
113: Ambrose AJ, Zerio C, Schmidlin C, Sivinski J, Shi T, Ross AB, Widrick KJ, Johnson SM, Zhang DD, Chapman E. A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78. Bioorg. Med. Chem. Lett. 2019. PMID:31129054.
112: Shi T, Zerio CJ, Sivinski J, Ambrose AJ, Moore KT, Buckley T, Kaneko L, Zhang M, Zhang DD, and Chapman E. A one-step, atom economical synthesis of thieno[2,3-d]pyrimidin-4-amine derivatives via a four-component reaction. Eur. J. Org. Chem. 2019. PMID:31857792.
111: Xiao Y, Riahi R, Torab P, Zhang DD, Wong PK. Collective Cell Migration in 3D Epithelial Wound Healing. ACS Nano. 2019. PMID:30758172.
110: Liu P, Rojo de la Vega M, Sammani S, Mascarenhas JB, Kerins M, Dodson M, Sun X, Wang T, Ooi A, Garcia JGN, Zhang DD. RPA1 binding to NRF2 switches ARE-dependent transcriptional activation to ARE-NRE-dependent repression. Proc Natl Acad Sci U S A. 2018. PMID:30309964
109: Yang Y, Kong S, Zhang Y, Melo-Cardenas J, Gao B, Zhang Y, Zhang DD, Zhang B, Song J, Thorp E, Zhang K, Zhang J, Fang D. The endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls a critical checkpoint in B cell development in mice. J Biol Chem. 2018. PMID:29907570
108: Wei J, Yuan Y, Xu Y, Chen L, Zhang Y, Wang Y, Yang Y, Peek CB, Diebold L, Yang Y, Gao B, Jin C, Melo-Cardenas J, Chandel NS, Zhang DD, Pan H, Zhang K, Wang J, He F, Fang D. ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes. Nat Commun. 2018. PMID:30201971
107: Ray S, Corenblum MJ, Anandhan A, Reed A, Ortiz FO, Zhang DD, Barnes CA, and Madhavan L. 2018. A role for Nrf2 expression in defining the aging of hippocampal neural stem cells. Cell transplantation. Cell Transplant. 2018. PMID:29871525
106: Rojo de la Vega M, Zhang DD*, Wondrak GT*. Topical Bixin Confers NRF2-Dependent Protection Against Photodamage and Hair Graying in Mouse Skin. Front Pharmacol. 2018. PMID:2963669
105: Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, Rojo de la Vega M, Cholanians AB, Wong PK, Chapman E, Zhang DD. Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction. Mol Cell Biol. 2018. PMID:29507186
104: Dodson M, de la Vega MR, Harder B, Castro-Portuguez R, Rodrigues SD, Wong PK, Chapman E, Zhang DD. Low-level arsenic causes proteotoxic stress and not oxidative stress. Toxicol Appl Pharmacol. 2018. PMID:29408041
103: Wang S, Xiao Y, Zhang DD, Wong PK. Non-Canonical activation of NRF2: A gapmer aptamer nanobiosensor for real-time monitoring of transcription and translation in single cells. Biomaterials. 2018. PMID:29190498.
102: Tian W, Rojo de la Vega M, Schmidlin CJ, Ooi A, Zhang DD. Kelch-like ECH-associated protein 1 (KEAP1) differentially regulates nuclear factor erythroid-2-related factors 1 and 2 (NRF1 and NRF2). J Biol Chem. 2018. PMID:29255090.
101: Wang S, Sun J, Xiao Y, Lu Y, Zhang DD, Wong PK. Intercellular Tension Negatively Regulates Angiogenic Sprouting of Endothelial Tip Cells via Notch1-Dll4 Signaling. Advanced Biosystems. 2017. PMID:30662935.
100: Tao S, de la Vega MR, Chapman E, Ooi A, Zhang DD. The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer. Mol Carcinog. 2018. PMID:28976703.
99: Tillotson J, Kedzior M, Guimarães L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodríguez AD, Schatz JH, Chapman E. ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett. 2017. PMID:28757063.
98: Tillotson J, Zerio CJ, Harder B, Ambrose AJ, Jung KS, Kang M, Zhang DD*, Chapman E*. Arsenic Compromises Both p97 and Proteasome Functions. Chem Res Toxicol. 2017. PMID:28636814.
97: Bao L, Wu J, Dodson M, Rojo de la Vega EM, Ning Y, Zhang Z, Yao M, Zhang DD, Xu C, Yi X. ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in ovarian cancer cells. Mol Carcinog. 2017. PMID:28112439.
96: Gao B, Kong Q, Zhang Y, Yun C, Dent SYR, Song J, Zhang DD, Wang Y, Li X, Fang D. The Histone Acetyltransferase Gcn5 Positively Regulates T Cell Activation. J Immunol. 2017. PMID:28424240.
95: Harder B, Tian W, La Clair JJ, Tan AC, Ooi A, Chapman E, Zhang DD. Brusatol overcomes chemoresistance through inhibition of protein translation. Mol Carcinog. 2017. PMID:28019675
94: Tao S, Liu P, Luo G, Rojo de la Vega M, Chen H, Wu T, Tillotson J, Chapman E, Zhang DD. p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex. Mol Cell Biol. 2017. PMID:28115426.
93: Wang S, Sun J, Zhang DD, Wong PK. A nanobiosensor for dynamic single cell analysis during microvascular self-organization. Nanoscale. 2016. PMID:27547924
92: Kong S, Yang Y, Xu Y, Wang Y, Zhang Y, Melo-Cardenas J, Xu X, Gao B, Thorp EB, Zhang DD, Zhang B, Song J, Zhang K, Zhang J, Zhang J, Li H, Fang D. Endoplasmic reticulum-resident E3 ubiquitin ligase Hrd1 controls B-cell immunity through degradation of the death receptor CD95/Fas. Proc Natl Acad Sci U S A.2016. PMID:27573825
91: Xu Y, Zhao F, Qiu Q, Chen K, Wei J, Kong Q, Gao B, Melo-Cardenas J, Zhang B, Zhang J, Song J, Zhang DD, Zhang J, Fan Y, Li H, Fang D. The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity. Nat Commun. 2016. PMID:27417417
90: Sun J, Hoying JB, Deymier PA, Zhang DD, Wong PK. Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility. PLoS Comput Biol. 2016. PMID:27196735
89: Corenblum MJ, Ray S, Remley QW, Long M, Harder B, Zhang DD, Barnes CA, Madhavan L. Reduced Nrf2 expression mediates the decline in neural stem cell function during a critical middle-age period. Aging Cell. 2016. PMID:27095375
88: Tang Q, Liang M, Lu Y, Wong PK, Wilmink GJ, Zhang DD, Xin H. Microfluidic Devices for Terahertz Spectroscopy of Live Cells Toward Lab-on-a-Chip Applications. Sensors (Basel). 2016. PMID:27049392
87: Wang H, Liu X, Long M, Hunag Y, Zhang L, Zhang R, Zheng Y, Liao X, Wang Y, Liao Q, Li W, Tang Z, Tong Q, Wang X, Fang F, Long M, Rojo de la Vega M, Ouyang Q, Zhang DD*, Yu S*, and Zheng H*. NRF2 activation by anti-diabetic agents accelerates tumor metastasis. Sci Transl Med. 2016. PMID:27075625
86: Melo-Cardenas J, Zhang Y, Zhang DD, Fang D. Ubiquitin-specific peptidase 22 functions and its involvement in disease. Oncotarget. 2016. PMID:27057639
85: Wang Y, Wang Y, Zhang Z, Park JY, Guo D, Liao H, Yi X, Zheng Y, Zhang DD, Chambers SK, Zheng W. Mechanism of progestin resistance in endometrial precancer/cancer through Nrf2-AKR1C1 pathway. Oncotarget. 2016. PMID:26824415
84: Chen W, Li S, Li J, Zhou W, Wu S, Xu S, Cui K, Zhang DD, Liu B. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury. FASEB J. 2016. PMID:27006451
83: Tao S, Rojo de la Vega M, Quijada H, Wondrak GT, Wang T, Garcia JG, Zhang DD. Bixin protects mice against ventilation-induced lung injury in an NRF2-dependent manner. Sci Rep. 2016. PMID:26729554
82: Long M, Rojo de la Vega M, Wen Q, Bharara M, Jiang T, Zhang R, Zhou S, Wong PK, Wondrak GT, Zheng H, Zhang DD. An Essential Role of NRF2 in Diabetic Wound Healing. Diabetes. 2016. PMID:26718502
81: Yin YW, Jin HJ, Zhao W, Gao B, Fang J, Wei J, Zhang DD, Zhang J, Fang D. The Histone Acetyltransferase GCN5 Expression Is Elevated and Regulated by c-Myc and E2F1 Transcription Factors in Human Colon Cancer. Gene Expr. 2015. PMID:26637399
80: Qian Z, Zhou T, Gurguis CI, Xu X, Wen Q, Lv J, Fang F, Hecker L, Cress AE, Natarajan V, Jacobson JR, Zhang DD, Garcia JG, Wang T. Nuclear factor, erythroid 2-like 2-associated molecular signature predicts lung cancer survival. Sci Rep. 2015. PMID:26596768
79: Tao S, Park SL, de la Vega MR, Zhang DD, Wondrak GT. Systemic administration of the pocarotenoid bixin protects skin against solar UV-induced damage through activation of NRF2. Free Radic Biol Med. 2015. PMID:26456052
78: Wang S, Riahi R, Li N, Zhang DD, Wong PK. Biosensors: Single Cell Nanobiosensors for Dynamic Gene Expression Profiling in Native Tissue Microenvironments (Adv. Mater. 39/2015). Adv Mater. 2015. PMID:26466935
77: Tao S, Tillotson J, Wijeratne EM, Xu YM, Kang M, Wu T, Lau EC, Mesa C, Mason DJ, Brown RV, La Clair JJ, Gunatilaka AA, Zhang DD* and Chapman E*. Withaferin A Analogs That Target the AAA+ Chaperone p97. ACS Chem Biol. 2015. PMID:26006219
76: Shen T, Jiang T, Long M, Chen J, Ren D, Wong PK, Chapman E, Zhou B and Zhang DD. A curcumin derivative that inhibits vinyl carbamate-induced lung carcinogenesis via activation of the Nrf2 protective response. Antioxid Redox Signal. 2015. PMID:25891177
75: Riahi R, Sun J, Wang S, Long M, Zhang DD, Wong PK. Notch1-Dll4 signalling and mechanical force regulate leader cell formation during collective cell migration. Nat Commun. 2015. PMID:25766473
74: Long M, Tao S, Rojo de la Vega M, Jiang T, Wen Q, Park SL, Zhang DD*, Wondrak GT*. Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. Cancer Prev Res. 2015. PMID:25712056
73: Bao L, Jaramillo MC, Zhang Z, Zheng Y, Yao M, Zhang DD, Yi X. Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cells. Mol Med Rep. 2015. PMID:25322694
72: Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, Cherrington NJ. Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene. Drug Metab Dispos. 2015. PMID:25349122
71: Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD. Oncogenic KRAS confers chemoresistance by upregulating NRF2. Cancer Res. 2014. PMID:25339352.
70: Nam KH, Jamilpour N, Mfoumou E, Wang FY, Zhang DD, Wong PK. Probing mechanoregulation of neuronal differentiation by plasma lithography patterned elastomeric substrates. Sci Rep. 2014. PMID:25376886
69: Kang MJ, Wu T, Wijeratne EM, Lau EC, Mason DJ, Mesa C, Tillotson J, Zhang DD, Gunatilaka AA, La Clair JJ, Chapman E. Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action. Chembiochem. 2014. PMID:25125376
68: Wu T, Harder BG, Wong PK, Lang JE, Zhang DD. Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy? Mol Carcinog. 2014. PMID:25154499.
67: Riahi R, Wang S, Long M, Li N, Chiou PY, Zhang DD, Wong PK. Mapping photothermally induced gene expression in living cells and tissues by nanorod-locked nucleic acid complexes. ACS Nano. 2014. PMID:24645754
66: Wu T, Zhao F, Gao B, Tan C, Yagishita N, Nakajima T, Wong PK, Chapman E, Fang D, Zhang DD. Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev. 2014. PMID:24636985
65: Shen T, Chen XM, Harder B, Long M, Wang XN, Lou HX, Wondrak GT, Ren DM, Zhang DD. Plant extracts of the family Lauraceae: a potential resource for chemopreventive agents that activate the nuclear factor-erythroid 2-related factor 2/antioxidant response element pathway. Planta Med. 2014. PMID:24585092
64: Riahi R, Long M, Yang Y, Dean Z, Zhang DD, Slepian MJ, Wong PK. Single cell gene expression analysis in injury-induced collective cell migration. Integr Biol (Camb). 2014. PMID:24336811
63: Wu T, Wang XJ, Tian W, Jaramillo MC, Lau A, Zhang DD. Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. Free Radic Biol Med. 2014. PMID:24140708
62: Jiang T, Tian F, Zheng H, Whitman SA, Lin Y, Zhang Z, Zhang N, Zhang DD. Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory response. Kidney Int. 2014. PMID:24025640
61: Bao LJ, Jaramillo MC, Zhang ZB, Zheng YX, Yao M, Zhang DD, Yi XF. Nrf2 induces cisplatin resistance through activation of autophagy in ovarian carcinoma. Int J Clin Exp Pathol. 2014. PMID:24817946
60: Qiao S, Tao S, Rojo de la Vega M, Park SL, Vonderfecht AA, Jacobs SL, Zhang DD, Wondrak GT. The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death. Autophagy. 2013. PMID:24113242
59: Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, Wong PK, Wondrak GT, Zhang DD. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro and in vivo. Antioxid Redox Signal. 2013. PMID:23394605
58: Whitman SA, Long M, Wondrak GT, Zheng H, Zhang DD. Nrf2 modulates contractile and metabolic properties of skeletal muscle in streptozotocin-induced diabetic atrophy. Exp Cell Res. 2013. PMID:23896025
57: Qiu Q, Zheng Z, Chang L, Zhao YS, Tan C, Dandekar A, Zhang Z, Lin Z, Gui M, Li X, Zhang T, Kong Q, Li H, Chen S, Chen A, Kaufman RJ, Yang WL, Lin HK, Zhang D, Perlman H, Thorp E, Zhang K, Fang D. Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. EMBO J. 2013. PMID:23942232
56: Riahi R, Dean Z, Wu TH, Teitell MA, Chiou PY, Zhang DD, Wong PK. Detection of mRNA in living cells by double-stranded locked nucleic acid probes. Analyst. 2013. PMID:23772441
55: Chen W, Wang H, Tao S, Zheng Y, Wu W, Lian F, Jaramillo M, Fang D, Zhang DD. Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival. Cell Cycle. 2013. PMID:24067374
54: Villeneuve NF, Tian W, Wu T, Sun Z, Lau A, Chapman E, Fang D, Zhang DD. USP15 negatively regulates Nrf2 through deubiquitination of Keap1. Mol Cell. 2013. PMID:23727018
53: Lau A, Zheng Y, Tao S, Wang H, Whitman SA, White E, Zhang DD. Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. Mol Cell Biol. 2013. PMID:23589329
52: Lu Y, Gao J, Zhang DD, Gau V, Liao JC, Wong PK. Single cell antimicrobial susceptibility testing by confined microchannels and electrokinetic loading. Anal Chem. 2013. PMID:234452
51: Wu W, Qiu Q, Wang H, Whitman SA, Fang D, Lian F, Zhang DD. Nrf2 is crucial to graft survival in a rodent model of heart transplantation. Oxid Med Cell Longev. 2013. PMID:23533698
50: Ji L, Li H, Gao P, Shang G, Zhang DD, Zhang N, Jiang T. Nrf2 pathway regulates multidrug-resistance-associated protein 1 in small cell lung cancer. PLoS One. 2013. PMID:23667609
49: Tao S, Justiniano R, Zhang DD, Wondrak GT. The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV. Redox Biol. 2013. PMID:24273736
48: Zheng Y, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. Toxicol Appl Pharmacol. 2012. PMID:22975029
47: Chen W, Jiang T, Wang H, Tao S, Lau A, Fang D, Zhang DD. Does Nrf2 contribute to p53-mediated control of cell survival and death? Antioxid Redox Signal. 2012. PMID:22559194
46: Wang F, Tian F, Whitman SA, Zhang DD, Nishinaka T, Zhang N, Jiang T. Regulation of transforming growth factor β1-dependent aldose reductase expression by the Nrf2 signal pathway in human mesangial cells. Eur J Cell Biol. 2012. PMID:22951256
45: Hu Q, Zhang DD, Wang L, Lou H, Ren D. Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity. Food Chem Toxicol. 2012. PMID:22465804
44: Lin Z, Yang H, Kong Q, Li J, Lee SM, Gao B, Dong H, Wei J, Song J, Zhang DD, Fang D. USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. Mol Cell. 2012. PMID:22542455
43: Ma J, Cai H, Wu T, Sobhian B, Huo Y, Alcivar A, Mehta M, Cheung KL, Ganesan S, Kong AN, Zhang DD, Xia B. PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function. Mol Cell Biol. 2012. PMID:22331464
42: Riahi R, Yang Y, Zhang DD, Wong PK. Advances in wound-healing assays for probing collective cell migration. J Lab Autom. 2012. PMID:22357609
41: Bray K, Mathew R, Lau A, Kamphorst JJ, Fan J, Chen J, Chen HY, Ghavami A, Stein M, DiPaola RS, Zhang D, Rabinowitz JD, White E. Autophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibition. PLoS One. 2012. PMID:22848625
40: Zheng H, Whitman SA, Wu W, Wondrak GT, Wong PK, Fang D, Zhang DD. Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. Diabetes. 2011. PMID:22025779
39: Kong S, Kim SJ, Sandal B, Lee SM, Gao B, Zhang DD, Fang D. The type III histone deacetylase Sirt1 protein suppresses p300-mediated histone H3 lysine 56 acetylation at Bclaf1 promoter to inhibit T cell activation. J Biol Chem. 2011. PMID:21454709
38: Sun Z, Wu T, Zhao F, Lau A, Birch CM, Zhang DD. KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response. Mol Cell Biol. 2011. PMID:21383067
37: Ren D, Villeneuve NF, Jiang T, Wu T, Lau A, Toppin HA, Zhang DD. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Proc Natl Acad Sci U S A. 2011. PMID:21205897
36: Chen N, Yi X, Abushahin N, Pang S, Zhang D, Kong B, Zheng W. Nrf2 expression in endometrial serous carcinomas and its precancers. Int J Clin Exp Pathol. 2010. PMID:21228930
35: Chen HC, Gau V, Zhang DD, Liao JC, Wang FY, Wong PK. Statistical metamodeling for revealing synergistic antimicrobial interactions. PLoS One. 2010. PMID:21124958
34: Lau A, Wang XJ, Zhao F, Villeneuve NF, Wu T, Jiang T, Sun Z, White E, Zhang DD. A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62. Mol Cell Biol. 2010. PMID:20421418
33: Jiang T, Chen N, Zhao F, Wang XJ, Kong B, Zheng W, Zhang DD. High levels of Nrf2 determine chemoresistance in type II endometrial cancer. Cancer Res. 2010. PMID:20530669
32: Hur W, Sun Z, Jiang T, Mason DE, Peters EC, Zhang DD, Luesch H, Schultz PG, Gray NS. A small-molecule inducer of the antioxidant response element. Chem Biol. 2010. PMID:20534351
31: Wondrak GT, Villeneuve NF, Lamore SD, Bause AS, Jiang T, Zhang DD. The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.Molecules. 2010. PMID:20657484
30: Jiang T, Huang Z, Lin Y, Zhang Z, Fang D, Zhang DD. The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. Diabetes. 2010. PMID:20103708
29: Chen CH, Lu Y, Sin ML, Mach KE, Zhang DD, Gau V, Liao JC, Wong PK. Antimicrobial susceptibility testing using high surface-to-volume ratio microchannels. Anal Chem. 2010. PMID:20055494
28: Chen A, Gao B, Zhang J, McEwen T, Ye SQ, Zhang D, Fang D. The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. Mol Cell Biol. 2009. PMID:19651900
27: Jiang T, Huang Z, Chan JY, Zhang DD. Nrf2 protects against As(III)-induced damage in mouse liver and bladder. Toxicol Appl Pharmacol. 2009. PMID:19538980
26: Zhao F, Wu T, Lau A, Jiang T, Huang Z, Wang XJ, Chen W, Wong PK, Zhang DD. Nrf2 promotes neuronal cell differentiation. Free Radic Biol Med. 2009. PMID:19573594
25: Sun Z, Huang Z, Zhang DD. Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One. 2009. PMID:19668370
24: Gidwani V, Riahi R, Zhang DD, Wong PK. Hybridization kinetics of double-stranded DNA probes for rapid molecular analysis. Analyst. 2009. PMID:20448937
23: Chen W, Sun Z, Wang XJ, Jiang T, Huang Z, Fang D, Zhang DD. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell. 2009. PMID: 19560419
22: Sun Z, Chin YE, Zhang DD. Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol. 2009. PMID:19273602
21: Wang XJ, Zhang DD. Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. PLoS One. 2009. PMID:19424503
20: Du Y, Villeneuve NF, Wang XJ, Sun Z, Chen W, Li J, Lou H, Wong PK, Zhang DD. Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response.Environ Health Perspect. 2008. PMID:18795156
19: Wondrak GT, Cabello CM, Villeneuve NF, Zhang S, Ley S, Li Y, Sun Z, Zhang DD. Cinnamoyl-based Nrf2-activators targeting human skin cell photo-oxidative stress. Free Radic Biol Med. 2008. PMID:18482591
18: Wang Z, Gidwani V, Zhang DD, Wong PK. Separation-free detection of nuclear factor kappa B with double-stranded molecular probes. Analyst. 2008. PMID:18645638.
17: Meserve D, Wang Z, Zhang DD, Wong PK. A double-stranded molecular probe for homogeneous nucleic acid analysis. Analyst. 2008. PMID:18645642.
16: Wang XJ, Sun Z, Chen W, Li Y, Villeneuve NF, Zhang DD. Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. Toxicol Appl Pharmacol. 2008. PMID:18417180
15: Wang XJ, Sun Z, Villeneuve NF, Zhang S, Zhao F, Li Y, Chen W, Yi X, Zheng W, Wondrak GT, Wong PK, Zhang DD. Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2.Carcinogenesis. 2008. PMID:18413364
14: Gao B, Lee SM, Chen A, Zhang J, Zhang DD, Kannan K, Ortmann RA, Fang D. Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis. EMBO Rep. 2008. PMID:18369366
13: Wang XJ, Sun Z, Chen W, Eblin KE, Gandolfi JA, Zhang DD. Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. Toxicol Appl Pharmacol. 2007. PMID:17765279
12: Sun Z, Zhang S, Chan JY, Zhang DD. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2. Mol Cell Biol. 2007. PMID: 17636022
(Beginning of the independent position at University of Arizona)
11: Ansell PJ, Lo SC, Newton LG, Espinosa-Nicholas C, Zhang DD, Liu JH, Hannink M, Lubahn DB. Repression of cancer protective genes by 17beta-estradiol: ligand-dependent interaction between human Nrf2 and estrogen receptor alpha. Mol Cell Endocrinol. 2005. PMID:16198475
10: Zhang DD, Lo SC, Sun Z, Habib GM, Lieberman MW, Hannink M. Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway. J Biol Chem. 2005. PMID:15983046
9: Li X, Zhang D, Hannink M, Beamer LJ. Crystal structure of the Kelch domain of human Keap1. J Biol Chem. 2004. PMID:15475350
8: Zhang DD, Lo SC, Cross JV, Templeton DJ, Hannink M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol. 2004. PMID:15572695
7: Li X, Zhang D, Hannink M, Beamer LJ. Crystallization and initial crystallographic analysis of the Kelch domain from human Keap1. Acta Crystallogr D Biol Crystallogr. 2004. PMID:15583386
6: Zhang DD, Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol. 2003. PMID:14585973
5: Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol Cell Biol. 2003. PMID:14517290
4: Salnikow K, Davidson T, Kluz T, Chen H, Zhou D#, Costa M. GeneChip analysis of signaling pathways effected by nickel. J Environ Monit. 2003. PMID:12729255
3: Zhang DD, Hartsky MA, Warheit DB. Time course of quartz and TiO(2) particle-induced pulmonary inflammation and neutrophil apoptotic responses in rats. Exp Lung Res. 2002. PMID: 12490038
2: Sachdev S, Bagchi S, Zhang DD, Mings AC, Hannink M. Nuclear import of IkappaBalpha is accomplished by a ran-independent transport pathway. Mol Cell Biol. 2000. PMID:10669735
1: Zhou D#, Salnikow K, Costa M. Cap43, a novel gene specifically induced by Ni2+ compounds. Cancer Res. 1998. PMID:9605764
*Co-corresponding author
Reviews, Perspectives and Commentaries:
27: Zhang DD, Chapman E. The role of natural products in revealing NRF2 function. Nat Prod Rep. 2020. PMID:32400766
26: Anandhan A, Dodson M, Schmidlin CJ, Liu P, Zhang DD. Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis. Cell Chem Biol. 2020. PMID:32275864
25: Schmidlin CJ, Dodson MB, Zhang DD. Filtering through the role of NRF2 in kidney disease. Arch Pharm Res. 2019. PMID:31372933
24: Dodson M, Castro-Portuguez R, Zhang DD. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol. 2019. PMID:30692038.
23: Schmidlin CJ, Dodson MB, Madhavan L, Zhang DD. Redox regulation by NRF2 in aging and disease. Free Radic Biol Med. 2019. PMID:30654017.
22: Dodson M, de la Vega MR, Cholanians AB, Schmidlin CJ, Chapman E, Zhang DD. Modulating NRF2 in Disease: Timing Is Everything. Annu Rev Pharmacol Toxicol. 2018. PMID:30256716
21: Rojo de la Vega M, Chapman E, Zhang DD. NRF2 and the Hallmarks of Cancer. Cancer Cell. 2018. PMID:29731393
20: Rojo de la Vega M, Zhang DD. NRF2 Induction for NASH Treatment: A New Hope Rises. Cell Mol Gastroenterol Hepatol. 2018. PMID:29675456
19: Rojo de la Vega M, Krajisnik A, Zhang DD, Wondrak GT. Targeting NRF2 for Improved Skin Barrier Function and Photoprotection: Focus on the Achiote-Derived Apocarotenoid Bixin. Nutrients. 2017. Review. PMID:29258247
18: Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascón S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017. PMID:28985560.
17: Dodson M, Zhang DD. Non-Canonical activation of NRF2: New insights and its relevance to disease. Curr Pathobiol Rep. 2017. PMID:29082113.
16 Long M, Li X, Li L, Dodson M, Zhang DD, Zheng H. Multifunctional p62 Effects Underlie Diverse Metabolic Diseases. Trends Endocrinol Metab. 2017. PMID:28966079.
15: de la Vega MR, Dodson M, Chapman E, Zhang DD. NRF2-targeted therapeutics: New targets and modes of NRF2 regulation. Curr Opin Toxicol. 2016. PMID:29082352.
14: Wang H, Rojo de la Vega M, Zhang DD*, Yu S*, Zheng H*. Response to comment on "NRF2 activation by antioxidant antidiabetic agents accelerates tumor metastasis". Sci Transl Med. 2016. PMID:27464746
13: de la Vega MR, Dodson M, Gross C, Manzour H, Lantz RC, Chapman E, Wang T, Black SM, Garcia JG, Zhang DD. Role of Nrf2 and Autophagy in Acute Lung Injury. Curr Pharmacol Rep. 2016. PMID:27313980
12: Klionsky DJ, Abdelmohsen K, Abe A, et. al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016. PMID:26799652
11: Jiang T, Harder B, Rojo de la Vega M, Wong PK, Chapman E, Zhang DD. P62 links autophagy and NRF2 signaling. Free Radic Biol Med. 2015. PMID:26117325
10: Harder B, Jiang T, Wu T, Tao S, Rojo de la Vega M, Chapman E, Zhang DD. Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention. Biochem. Soc. Trans. 2015. PMID:26551712
9: Jaramillo MC, Zhang DD. The emerging role of the Nrf2-Keap1 signaling pathway in cancer. Genes Dev. 2013. PMID:24142871
8: Zhang DD. Bardoxolone brings Nrf2-based therapies to light. Antioxid Redox Signal. 2013. PMID:23227819
7: Lau A, Whitman SA, Jaramillo MC, Zhang DD. Arsenic-mediated activation of the Nrf2-Keap1 antioxidant pathway. J Biochem Mol Toxicol. 2013. PMID:23188707
6: Lau A, Tian W, Whitman SA, Zhang DD. The predicted molecular weight of Nrf2: it is what it is not. Antioxid Redox Signal. 2013. PMID:22703241
5: Villeneuve NF, Lau A, Zhang DD. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid Redox Signal. 2010. PMID:20486766
4: Zhang DD. The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer.Antioxid Redox Signal. 2010. PMID:20486759
3: Villeneuve NF, Sun Z, Chen W, Zhang DD. Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels. Cell Cycle. 2009. PMID:19806015
2: Lau A, Villeneuve NF, Sun Z, Wong PK, Zhang DD. Dual roles of Nrf2 in cancer. Pharmacol Res. 2008. PMID:18838122
1: Zhang DD. Mechanistic studies of the Nrf2-Keap1 signaling pathway. Drug Metab Rev. 2006. PMID:17145701
Book chapters:
3: Comprehensive Toxicology, 3rd Edition. Elsevier. Editor-in-Chiefs: Charlene McQueen. ISBN: 9780081006016 Chapter: Oxidative Signaling. de la Vega MR, Dodson M, Zhang DD. 2017
2: Johnson J, Puga A, Wallace KB, and Zhang DD. Editorial Overview: Nrf2 in Toxicology: An Update. Curr Opin Toxicol. 2016,1. Chapter: de la Vega MR, Dodson M, Chapman E, Zhang DD. NRF2-targeted therapeutics: New targets and modes of NRF2 regulation. Curr Opin Toxicol. 2016 Dec;1:62-70.
1: Zhang DD. 2010. The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer. Antioxid Redox Signal.
Chapter:
Villeneuve NF, Lau A, Zhang DD. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid Redox Signal. 2010 Dec 1;13(11):1699-712.
#Zhou D. is the former name of Zhang DD